Neonatal tetanus despite protective serum antitoxin concentration

Neonatal tetanus despite protective serum antitoxin concentration.

Using the ELISA technique to estimate serum antibodies against tetanus toxin, seven neonates with clinical tetanus were found to have antibody levels 4-13 times higher than the presumed minimum protective level of 0.01 IU/ml. All but one of their mothers had been vaccinated with tetanus toxoid in pregnancy. In two other neonates, whose mothers had received multiple booster doses of toxoid durin...

Human tetanus antitoxin.

Tetanus Antitoxin from Intraocular Transplants **

Evidence for antibody formation by various cells, tissues, and organs has come mainly from studies employing the following methods: (i) extracts of tissue cultures,'l (ii) cannulization of afferent and efferent lymph,"'X (iii) extracts of cells, tissues, and organs,"' (iv) extirpation of the spleen," and (v) roentgen-radiation of animals with lead-protected mobilized spleens.' Although the repo...

Protective effects of topical antimicrobials against neonatal tetanus.

BACKGROUND Case-control studies previously conducted in Pakistan suggested that topical antimicrobials might provide protection against neonatal tetanus (NNT) when applied to the umbilical cord wound during the first several days of life. The present case-control study, the largest such study yet reported, was undertaken in Punjab Province, Pakistan and afforded further opportunities to evaluat...

Tetanus antitoxin titres in military personnel.

A study was made of the titres of tetanus antitoxin in the sera of 186 recruits and 886 serving personnel. All were found to have titres of more than 0.01 IU per ml, the titre regarded as sufficient to provide protection from tetanus. The percentage of recruits with tetanus antitoxin titres less than 0.1 IU per ml was significantly greater than the percentage of serving personnel with antitoxin...